Standard Name	SMK1 1
Systematic Name	YPR054W
Feature Type	ORF, Verified
Description	Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p (1, 2, 3, 4)

Chromosomal Location	ChrXVI:666280 to 667446 | ORF Map | GBrowse

	View Computational GO annotations for SMK1
Molecular Function
Manually curated	MAP kinase activity (IDA, IMP, ISS)
Biological Process
Manually curated	ascospore wall assembly (IGI, IMP) negative regulation of sporulation resulting in formation of a cellular spore (IGI) protein phosphorylation (IDA, IMP, ISS)
Cellular Component
High-throughput	mitochondrion (IDA)

Resources	YeTFaSCo

Classical genetics
null	spore wall formation: abnormal
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent sporulation: decreased sporulation efficiency: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	53 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 1 Biochemical Activity: 2 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 3 Dosage Rescue: 1 Negative Genetic: 10 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 8 Synthetic Growth Defect: 1 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:666280 to 667446 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1167 666280..667446 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006258