SMI1/YGR229C Summary Help

Standard Name SMI1 1
Systematic Name YGR229C
Alias KNR4 2
Feature Type ORF, Verified
Description Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity (3, 4, 5)
Name Description Suppressor of MAR Inhibitor 1
Chromosomal Location
ChrVII:950899 to 949382 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SMI1 GO evidence and references
  View Computational GO annotations for SMI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
641 total interaction(s) for 298 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • PCA: 14
  • Reconstituted Complex: 2
  • Two-hybrid: 18

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 280
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 20
  • Positive Genetic: 29
  • Synthetic Growth Defect: 76
  • Synthetic Lethality: 180
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 505
Molecular Weight (Da) 57,079
Isoelectric Point (pI) 4.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:950899 to 949382 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1518 950899..949382 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003461
References cited on this page View Complete Literature Guide for SMI1
1) Fishel BR, et al.  (1993) Yeast calmodulin and a conserved nuclear protein participate in the in vivo binding of a matrix association region. Proc Natl Acad Sci U S A 90(12):5623-7
2) Hong Z, et al.  (1994) Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Mol Cell Biol 14(2):1017-25
3) Martin H, et al.  (1999) KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes. Microbiology 145 ( Pt 1)():249-58
4) Martin-Yken H, et al.  (2002) KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiae. Curr Genet 41(5):323-32
5) Martin-Yken H, et al.  (2003) The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae. Mol Microbiol 49(1):23-35