SMF3/YLR034C Summary Help

Standard Name SMF3 1
Systematic Name YLR034C
Feature Type ORF, Verified
Description Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress (1, 2, 3)
Chromosomal Location
ChrXII:211933 to 210512 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SMF3 GO evidence and references
  View Computational GO annotations for SMF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
35 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • PCA: 10
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 10
  • Positive Genetic: 1
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 473
Molecular Weight (Da) 51,775
Isoelectric Point (pI) 8.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:211933 to 210512 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1422 211933..210512 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000004024
References cited on this page View Complete Literature Guide for SMF3
1) Portnoy ME, et al.  (2000) Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol 20(21):7893-902
2) E Portnoy M, et al.  (2002) The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J 362(Pt 1):119-24
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76