SMF2/YHR050W Summary Help

Standard Name SMF2 1
Systematic Name YHR050W
Feature Type ORF, Verified
Description Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins (2, 3, 4)
Name Description Suppressor of Mitochondria import Function 1
Chromosomal Location
ChrVIII:207654 to 209303 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SMF2 GO evidence and references
  View Computational GO annotations for SMF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
repressible
unspecified
Resources
34 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • PCA: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 18
  • Phenotypic Enhancement: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 549
Molecular Weight (Da) 59,768
Isoelectric Point (pI) 5.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:207654 to 209303 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1650 207654..209303 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001092
References cited on this page View Complete Literature Guide for SMF2
1) West AH, et al.  (1992) Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J Biol Chem 267(34):24625-33
2) Chen XZ, et al.  (1999) Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents. J Biol Chem 274(49):35089-94
3) Luk EE and Culotta VC  (2001) Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem 276(50):47556-62
4) E Portnoy M, et al.  (2002) The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J 362(Pt 1):119-24