Standard Name	SMF2 1
Systematic Name	YHR050W
Feature Type	ORF, Verified
Description	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins (2, 3, 4)
Name Description	Suppressor of Mitochondria import Function 1

Chromosomal Location	ChrVIII:207654 to 209303 | ORF Map | GBrowse

	View Computational GO annotations for SMF2
Molecular Function
Manually curated	inorganic cation transmembrane transporter activity (IDA)
Biological Process
Manually curated	cellular cobalt ion homeostasis (IGI) cellular manganese ion homeostasis (IMP) cobalt ion transport (IGI) manganese ion transport (IMP)
Cellular Component
Manually curated	cytoplasmic membrane-bounded vesicle (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
null	manganese(2+) accumulation: normal manganese(2+) accumulation: increased manganese(2+) accumulation: decreased metal resistance: increased
Large-scale survey
null	competitive fitness: decreased resistance to calcium dichloride: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	31 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 PCA: 2
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 18 Phenotypic Enhancement: 3 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:207654 to 209303 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1650 207654..209303 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000001092