SMC6/YLR383W Summary Help

Standard Name SMC6
Systematic Name YLR383W
Alias RHC18 1
Feature Type ORF, Verified
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18 (2, 3, 4)
Name Description Structural Maintenance of Chromosomes
Chromosomal Location
ChrXII:885288 to 888632 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SMC6 GO evidence and references
  View Computational GO annotations for SMC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
Resources
106 total interaction(s) for 82 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Co-purification: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 40
  • Phenotypic Enhancement: 22
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 4
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,114
Molecular Weight (Da) 128,007
Isoelectric Point (pI) 7.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:885288 to 888632 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3345 885288..888632 2004-02-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004375
References cited on this page View Complete Literature Guide for SMC6
1) Lehmann AR, et al.  (1995) The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair. Mol Cell Biol 15(12):7067-80
2) Onoda F, et al.  (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) 3(4):429-39
3) Zhao X and Blobel G  (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82
4) Bermudez-Lopez M, et al.  (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12