Standard Name	SMC5
Systematic Name	YOL034W
Feature Type	ORF, Verified
Description	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair (1, 2, 3, 4, 5)
Name Description	Structural Maintenance of Chromosomes

Chromosomal Location	ChrXV:259923 to 263204 | ORF Map | GBrowse

	View Computational GO annotations for SMC5
Molecular Function
Manually curated	ATPase activity (IDA) damaged DNA binding (IDA) single-stranded DNA binding (IDA)
Biological Process
Manually curated	chromosome separation (IMP) DNA repair (IDA, IMP) recombinational repair (IPI) resolution of recombination intermediates (IMP)
Cellular Component
Manually curated	nucleus (IDA) Smc5-Smc6 complex (IDA)

Classical genetics
conditional	UV resistance: decreased chromosome segregation: abnormal heat sensitivity: increased Rad53p modification: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
null	viable
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	haploproficient inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
repressible	cell cycle progression in G1 phase: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	77 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 11 Biochemical Activity: 1 Co-crystal Structure: 1 Co-fractionation: 1 Co-purification: 3 Reconstituted Complex: 3 Two-hybrid: 30
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 2 Negative Genetic: 1 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:259923 to 263204 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3282 259923..263204 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005394