SLU7/YDR088C Summary

SLU7 BASIC INFORMATION

Standard Name	SLU7 1
Systematic Name	YDR088C
Alias	SLT17 2
Feature Type	ORF, Verified
Description	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain (3)
Name Description	Synergistic Lethal with U5 snRNA 1

GO Annotations	All SLU7 GO evidence and references
	View Computational GO annotations for SLU7
Molecular Function
Manually curated	contributes_to second spliceosomal transesterification activity (IDA)
Biological Process
Manually curated	generation of catalytic spliceosome for second transesterification step (IDA)
Cellular Component
Manually curated	spliceosomal complex (IDA)

Mutant Phenotype	All SLU7 Phenotype details and references
Classical genetics
conditional	lariat splicing intermediate accumulation: abnormal cold sensitivity: increased heat sensitivity: increased
Large-scale survey
null	inviable

Interactions	SLU7 All interactions details and references
	44 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 2 Co-fractionation: 4 Reconstituted Complex: 1 Two-hybrid: 12
Genetic Interactions	Dosage Rescue: 2 Phenotypic Suppression: 2 Synthetic Lethality: 14 Synthetic Rescue: 1

Sequence Information

ChrIV:619643 to 618495 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1149	619643..618495	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002495

SLU7 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SLU7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SLU7]

1)	Frank D, et al. (1992) Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol 12(11):5197-205
2)	Xu D, et al. (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
3)	James SA, et al. (2002) How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing. RNA 8(8):1068-77

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