Standard Name	SLN1 1
Systematic Name	YIL147C
Alias	YPD2
Feature Type	ORF, Verified
Description	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators (2, 3, 4)
Name Description	Synthetic Lethal of N-end rule 1

Chromosomal Location	ChrIX:73453 to 69791 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SLN1
Molecular Function
Manually curated	histidine phosphotransfer kinase activity (IDA, IMP) osmosensor activity (IDA) protein histidine kinase activity (IDA)
Biological Process
Manually curated	negative regulation of protein kinase activity (IGI, IMP) osmosensory signaling via phosphorelay pathway (IDA) peptidyl-histidine phosphorylation (IDA) protein autophosphorylation (IDA)
Cellular Component
Manually curated	integral to plasma membrane (IDA) plasma membrane (IDA, ISS)

Classical genetics
activation	YHP1 mRNA accumulation: increased hyperosmotic stress resistance: decreased
conditional	cell cycle progression in S phase: delayed
null	YHP1 mRNA accumulation: decreased inviable Mcm1p activity: decreased viable
reduction of function	resistance to pradimicins: increased vegetative growth: decreased rate
unspecified	resistance to hygromycin B: decreased resistance to caffeine: decreased
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased resistance to benomyl: decreased
repressible	chromosome/plasmid maintenance: decreased
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	59 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Biochemical Activity: 12 Co-crystal Structure: 2 PCA: 5 Reconstituted Complex: 2 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 9 Negative Genetic: 1 Phenotypic Suppression: 2 Positive Genetic: 7 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:73453 to 69791 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3663 73453..69791 1994-12-10 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001409