SLN1/YIL147C Summary Help

Standard Name SLN1 1
Systematic Name YIL147C
Alias YPD2
Feature Type ORF, Verified
Description Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators (2, 3, 4)
Name Description Synthetic Lethal of N-end rule 1
Chromosomal Location
ChrIX:73453 to 69791 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SLN1 GO evidence and references
  View Computational GO annotations for SLN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 74 genes
Resources
Classical genetics
activation
conditional
null
reduction of function
unspecified
Large-scale survey
null
overexpression
reduction of function
repressible
unspecified
Resources
61 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 12
  • Co-crystal Structure: 2
  • PCA: 5
  • Reconstituted Complex: 2
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 9
  • Negative Genetic: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 7
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 3
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,220
Molecular Weight (Da) 134,434
Isoelectric Point (pI) 7.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:73453 to 69791 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3663 73453..69791 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001409
References cited on this page View Complete Literature Guide for SLN1
1) Ota IM and Varshavsky A  (1993) A yeast protein similar to bacterial two-component regulators. Science 262(5133):566-9
2) Posas F, et al.  (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86(6):865-75
3) O'Rourke SM, et al.  (2002) Yeast go the whole HOG for the hyperosmotic response. Trends Genet 18(8):405-12
4) Reiser V, et al.  (2003) Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure. J Cell Biol 161(6):1035-40