SLH1/YGR271W Summary Help

Standard Name SLH1 1
Systematic Name YGR271W
Feature Type ORF, Verified
Description Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses (2, 3)
Name Description SKI2-Like Helicase 1
Chromosomal Location
ChrVII:1031791 to 1037694 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SLH1 GO evidence and references
  View Computational GO annotations for SLH1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
49 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-fractionation: 1
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 27
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 2
  • Positive Genetic: 4
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,967
Molecular Weight (Da) 224,849
Isoelectric Point (pI) 6.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1031791 to 1037694 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..5904 1031791..1037694 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003503
References cited on this page View Complete Literature Guide for SLH1
1) Searfoss AM and Wickner RB  (2000) 3' poly(A) is dispensable for translation. Proc Natl Acad Sci U S A 97(16):9133-7
2) Searfoss A, et al.  (2001) Linking the 3' poly(A) tail to the subunit joining step of translation initiation: relations of Pab1p, eukaryotic translation initiation factor 5b (Fun12p), and Ski2p-Slh1p. Mol Cell Biol 21(15):4900-8
3) de la Cruz J, et al.  (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8