SLF1/YDR515W Summary Help

Standard Name SLF1 1
Systematic Name YDR515W
Alias SRO99
Feature Type ORF, Verified
Description RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description SuLFide production 1
Chromosomal Location
ChrIV:1473429 to 1474772 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SLF1 GO evidence and references
  View Computational GO annotations for SLF1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
535 total interaction(s) for 531 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 515
  • Co-fractionation: 2
  • PCA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 447
Molecular Weight (Da) 50,943
Isoelectric Point (pI) 10.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1473429 to 1474772 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1344 1473429..1474772 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002923
References cited on this page View Complete Literature Guide for SLF1
1) Yu W, et al.  (1996) Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae. Mol Cell Biol 16(5):2464-72
2) Sobel SG and Wolin SL  (1999) Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes. Mol Biol Cell 10(11):3849-62
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76