Standard Name	SLD7 1
Systematic Name	YOR060C
Alias	YOR29-11
Feature Type	ORF, Verified
Description	Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria (1, 2)
Name Description	Synthetic Lethality with Dpb11-24 1

Chromosomal Location	ChrXV:441163 to 440390 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SLD7
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	regulation of DNA-dependent DNA replication initiation (IGI, IPI)
Cellular Component
Manually curated	DNA replication preinitiation complex (IDA)
High-throughput	cytoplasm (IDA) endoplasmic reticulum (IDA) nuclear envelope (IDA) nucleus (IDA) colocalizes_with spindle pole body (IDA)

Classical genetics
conditional	telomere length: decreased
null	growth in exponential phase: increased rate resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal colony sectoring: increased heat sensitivity: increased
null	inviable
reduction of function	competitive fitness: increased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	26 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Co-fractionation: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 5 Dosage Rescue: 4 Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:441163 to 440390 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..774 441163..440390 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005586