SKY1/YMR216C Summary

SKY1 BASIC INFORMATION

Standard Name	SKY1 1
Systematic Name	YMR216C
Feature Type	ORF, Verified
Description	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 (1, 2)
Name Description	SRPK1-like Kinase in Yeast 1

GO Annotations	All SKY1 GO evidence and references
	View Computational GO annotations for SKY1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
Biological Process
Manually curated	cellular cation homeostasis (IMP) cellular ion homeostasis (IMP) mRNA splice site selection (IGI) positive regulation of protein import into nucleus (IMP) protein amino acid phosphorylation (IDA) response to drug (IMP)
High-throughput	regulation of cell size (IMP)
Cellular Component
Manually curated	cytoplasm (IDA)

Mutant Phenotype	All SKY1 Phenotype details and references
Classical genetics
null	resistance to rapamycin: increased
Large-scale survey
null	cell size: decreased competitive fitness: decreased hyperosmotic stress resistance: increased resistance to cisplatin: increased resistance to citric acid: decreased resistance to mycophenolic acid: decreased resistance to ethanol: decreased resistance to doxorubicin: decreased resistance to BPS: decreased toxin resistance: increased viable

Interactions	SKY1 All interactions details and references
	View additional details at BioGRID
	197 total interaction(s) for 153 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-Western: 1 Biochemical Activity: 47 Reconstituted Complex: 3 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 2 Negative Genetic: 79 Phenotypic Enhancement: 9 Phenotypic Suppression: 4 Positive Genetic: 30 Synthetic Growth Defect: 1 Synthetic Lethality: 5 Synthetic Rescue: 4

Sequence Information

ChrXIII:701038 to 698810 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2229	701038..698810	1996-07-31	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004829

SKY1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SKY1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SKY1]

1)	Siebel CW, et al. (1999) Conservation in budding yeast of a kinase specific for SR splicing factors. Proc Natl Acad Sci U S A 96(10):5440-5
2)	Forment J, et al. (2002) The yeast SR protein kinase Sky1p modulates salt tolerance, membrane potential and the Trk1,2 potassium transporter. Biochim Biophys Acta 1565(1):36-40

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.