SKT5/YBL061C Summary Help

Standard Name SKT5
Systematic Name YBL061C
Alias CAL2 , CHS4 , CSD4
Feature Type ORF, Verified
Description Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Chromosomal Location
ChrII:107406 to 105316 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SKT5 GO evidence and references
  View Computational GO annotations for SKT5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
reduction of function
Large-scale survey
null
overexpression
Resources
289 total interaction(s) for 159 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 8
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 2
  • Dosage Rescue: 3
  • Negative Genetic: 123
  • Positive Genetic: 4
  • Synthetic Growth Defect: 44
  • Synthetic Lethality: 72
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 696
Molecular Weight (Da) 77,066
Isoelectric Point (pI) 10.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:107406 to 105316 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2091 107406..105316 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000157
References cited on this page View Complete Literature Guide for SKT5
1) Ono N, et al.  (2000) The yeast Chs4 protein stimulates the trypsin-sensitive activity of chitin synthase 3 through an apparent protein-protein interaction. Microbiology 146 ( Pt 2):385-91
2) Trilla JA, et al.  (1997) Characterization of CHS4 (CAL2), a gene of Saccharomyces cerevisiae involved in chitin biosynthesis and allelic to SKT5 and CSD4. Yeast 13(9):795-807
3) Sanz M, et al.  (2002) Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation. Mol Microbiol 43(5):1183-95
4) Kozubowski L, et al.  (2003) A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Mol Biol Cell 14(1):26-39
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61