Standard Name	SKP2 1
Systematic Name	YNL311C
Feature Type	ORF, Verified
Description	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments (1, 2, 3)
Name Description	homology with human SKP2

Chromosomal Location	ChrXIV:51688 to 49397 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SKP2
Molecular Function
Manually curated	protein binding, bridging (ISA) contributes_to ubiquitin-protein ligase activity (IPI)
Biological Process
Manually curated	cellular protein catabolic process (IMP) regulation of sulfur amino acid metabolic process (IMP) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (ISA)
Cellular Component
Manually curated	SCF ubiquitin ligase complex (IDA, IPI)
High-throughput	colocalizes_with ribosome (IDA)

Classical genetics
null	chronological lifespan: decreased
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal resistance to methylmercury chloride: normal resistance to methylmercury chloride: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to glycolaldehyde: decreased sporulation: abnormal vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 1 Reconstituted Complex: 4 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 1 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:51688 to 49397 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2292 51688..49397 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005255