SKP1/YDR328C Summary Help

SKP1 BASIC INFORMATION

Standard Name SKP1 1
Systematic Name YDR328C
Alias MGO1
Feature Type ORF, Verified
Description Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase (2, 3)
Also known as: CBF3D 4
Name Description Suppressor of Kinetochore Protein mutant 2
GO Annotations All SKP1 GO evidence and references
    View Computational GO annotations for SKP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SKP1 Phenotype details and references
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
Interactions SKP1 All interactions details and references
280 total interaction(s) for 116 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 91
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 69
  • Biochemical Activity: 5
  • Co-crystal Structure: 1
  • Co-purification: 3
  • Reconstituted Complex: 33
  • Two-hybrid: 47
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 6
Sequence Information
ChrIV:1126014 to 1125430 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..585 1126014..1125430 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002736

SKP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SKP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SKP1]

1) Connely, C.J. and P. Hieter  (1996) Saccharomyces cerevisiae suppressor of kinetochore protein 1 (SKP1) Gene, complete cds. Unpublished
2) Connelly C and Hieter P  (1996) Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell 86(2):275-85
3) Seol JH, et al.  (2001) Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nat Cell Biol 3(4):384-91
4) Stemmann O and Lechner J  (1996) The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. EMBO J 15(14):3611-20