SKO1/YNL167C Summary Help

Standard Name SKO1 1
Systematic Name YNL167C
Alias ACR1 2
Feature Type ORF, Verified
Description Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses (1, 3, 4, 5, 6, 7)
Name Description Suppressor of Kinase Overexpression 1
Chromosomal Location
ChrXIV:321359 to 319416 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -110 cM
Gene Ontology Annotations All SKO1 GO evidence and references
  View Computational GO annotations for SKO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 32 genes
Regulators 3 genes
Classical genetics
Large-scale survey
63 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Biochemical Activity: 6
  • Co-localization: 1
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 11
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 8
  • Positive Genetic: 4
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 4

Expression Summary
Length (a.a.) 647
Molecular Weight (Da) 70,191
Isoelectric Point (pI) 10.09
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIV:321359 to 319416 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -110 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1944 321359..319416 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005111
References cited on this page View Complete Literature Guide for SKO1
1) Nehlin JO, et al.  (1992) Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. Nucleic Acids Res 20(20):5271-8
2) Vincent AC and Struhl K  (1992) ACR1, a yeast ATF/CREB repressor. Mol Cell Biol 12(12):5394-405
3) Rep M, et al.  (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83
4) Serrano R and Rodriguez-Navarro A  (2001) Ion homeostasis during salt stress in plants. Curr Opin Cell Biol 13(4):399-404
5) Pascual-Ahuir A, et al.  (2001) Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress. J Biol Chem 276(40):37373-8
6) Proft M and Struhl K  (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17
7) Tomas-Cobos L, et al.  (2004) Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. J Biol Chem 279(21):22010-9