Standard Name	SIZ1 1
Systematic Name	YDR409W
Alias	ULL1 2
Feature Type	ORF, Verified
Description	SUMO/Smt3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring; SIZ1 has a paralog, NFI1, that arose from the whole genome duplication (3, 4, 5)
Name Description	SAP and mIZ-finger domain 1

Chromosomal Location	ChrIV:1289406 to 1292120 | ORF Map | GBrowse

	View Computational GO annotations for SIZ1
Molecular Function
Manually curated	SUMO ligase activity (IDA, IMP, IPI)
Biological Process
Manually curated	chromosome segregation (IMP) protein sumoylation (IMP, ISS)
Cellular Component
Manually curated	nuclear chromatin (IDA) septin ring (IDA)

Classical genetics
null	mutation frequency: decreased Mot1p modification: decreased Rpo21p modification: decreased resistance to canavanine: decreased
Large-scale survey
null	UV resistance: decreased chronological lifespan: decreased competitive fitness: decreased haploproficient resistance to benzo[a]pyrene: decreased resistance to doxorubicin: increased resistance to bleomycin: increased resistance to fluconazole: increased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to methyl methanesulfonate: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	143 total interaction(s) for 68 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 11 Co-crystal Structure: 1 Reconstituted Complex: 5 Two-hybrid: 8
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 9 Phenotypic Enhancement: 13 Phenotypic Suppression: 20 Positive Genetic: 3 Synthetic Growth Defect: 33 Synthetic Lethality: 7 Synthetic Rescue: 20
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1289406 to 1292120 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2715 1289406..1292120 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002817