SIW14/YNL032W Summary Help

Standard Name SIW14 1
Systematic Name YNL032W
Alias OCA3 2
Feature Type ORF, Verified
Description Tyrosine phosphatase involved in actin organization and endocytosis; localized to the cytoplasm (3, 4, 5)
Name Description Synthetic Interaction with Whi2 1
Chromosomal Location
ChrXIV:574506 to 575351 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SIW14 GO evidence and references
  View Computational GO annotations for SIW14
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 44 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
141 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 4
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 70
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 25
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 281
Molecular Weight (Da) 32,755
Isoelectric Point (pI) 5.37
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:574506 to 575351 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..846 574506..575351 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004977
References cited on this page View Complete Literature Guide for SIW14
1) Binley KM, et al.  (1999) The yeast PRS3 gene is required for cell integrity, cell cycle arrest upon nutrient deprivation, ion homeostasis and the proper organization of the actin cytoskeleton. Yeast 15(14):1459-69
2) Warringer, J, et al.  (2006) personal communication
3) Sakumoto N, et al.  (2002) A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast 19(7):587-99
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Care A, et al.  (2004) A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae. Genetics 166(2):707-19