Standard Name	SIL1 1 (see Nomenclature conflict Note)
Systematic Name	YOL031C
Alias	SLS1 2
Feature Type	ORF, Verified
Description	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein (1, 2, 3)
Name Description	Suppressor of the Ire1/Lhs1 double mutant 1

Chromosomal Location	ChrXV:267529 to 266264 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SIL1
Molecular Function
Manually curated	adenyl-nucleotide exchange factor activity (IDA, IPI)
Biological Process
Manually curated	SRP-dependent cotranslational protein targeting to membrane, translocation (IGI, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IPI)

Classical genetics
null	resistance to tunicamycin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: normal viable
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased resistance to tunicamycin: decreased resistance to sirolimus: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	117 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 5 Co-crystal Structure: 1 Reconstituted Complex: 3 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 33 Phenotypic Enhancement: 32 Phenotypic Suppression: 14 Positive Genetic: 13 Synthetic Growth Defect: 2 Synthetic Lethality: 5 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:267529 to 266264 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1266 267529..266264 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005391