SIF2/YBR103W Summary Help

SIF2 BASIC INFORMATION

Standard Name SIF2 1
Systematic Name YBR103W
Alias EMB1 2
Feature Type ORF, Verified
Description WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus (1, 3, 4)
Name Description Sir4p-Interacting Factor 3
GO Annotations All SIF2 GO evidence and references
    View Computational GO annotations for SIF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SIF2 Phenotype details and references
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
Interactions SIF2 All interactions details and references
244 total interaction(s) for 147 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 54
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Two-hybrid: 9
Genetic Interactions
  • Phenotypic Enhancement: 99
  • Phenotypic Suppression: 36
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 25
  • Synthetic Rescue: 2
Sequence Information
ChrII:447703 to 449310 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1608 447703..449310 2004-07-16 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000307

SIF2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SIF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SIF2]

1) Gasser SM, et al.  (1998) Nuclear organization and silencing: trafficking of Sir proteins. Novartis Found Symp 214():114-26; discussion 126-32
2) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
3) Cockell M, et al.  (1998) Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast. Curr Biol 8(13):787-90
4) Pijnappel WW, et al.  (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004