SIC1/YLR079W Summary Help

SIC1 BASIC INFORMATION

Standard Name SIC1
Systematic Name YLR079W
Alias SDB25
Feature Type ORF, Verified
Description Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 (1, 2, 3, 4, 5, 6, 7, 8, 9)
Name Description Substrate/Subunit Inhibitor of Cyclin-dependent protein kinase 3
GO Annotations All SIC1 GO evidence and references
    View Computational GO annotations for SIC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle (275, 215)
Mutant Phenotype All SIC1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SIC1 All interactions details and references
  View additional details at BioGRID
504 total interaction(s) for 295 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 29
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 9
  • Biochemical Activity: 25
  • Co-crystal Structure: 1
  • PCA: 6
  • Reconstituted Complex: 10
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Lethality: 8
  • Dosage Rescue: 27
  • Negative Genetic: 220
  • Phenotypic Enhancement: 19
  • Phenotypic Suppression: 16
  • Positive Genetic: 25
  • Synthetic Growth Defect: 59
  • Synthetic Lethality: 37
  • Synthetic Rescue: 10
Sequence Information
ChrXII:286821 to 287675 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1997-07-30 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..855 286821..287675 1997-07-30 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004069

SIC1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SIC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SIC1]

1) Feldman RM, et al.  (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30
2) Schwob E, et al.  (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44
3) Nugroho TT and Mendenhall MD  (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8
4) Donovan JD, et al.  (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53
5) Mendenhall MD  (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9
6) Skowyra D, et al.  (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19
7) Verma R, et al.  (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60
8) Nash P, et al.  (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21
9) Barberis M, et al.  (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47