SHY1/YGR112W Summary Help

Standard Name SHY1 1
Systematic Name YGR112W
Feature Type ORF, Verified
Description Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase (1, 2, 3)
Name Description SURF Homolog of Yeast 1
Chromosomal Location
ChrVII:717358 to 718527 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SHY1 GO evidence and references
  View Computational GO annotations for SHY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
78 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 17
  • Co-fractionation: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 10
  • Negative Genetic: 13
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 389
Molecular Weight (Da) 45,056
Isoelectric Point (pI) 10.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:717358 to 718527 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1170 717358..718527 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003344
References cited on this page View Complete Literature Guide for SHY1
1) Mashkevich G, et al.  (1997) SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration. J Biol Chem 272(22):14356-64
2) Barrientos A, et al.  (2002) Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome. EMBO J 21(1-2):43-52
3) Mick DU, et al.  (2007) Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J 26(20):4347-58