Standard Name	SHY1 1
Systematic Name	YGR112W
Feature Type	ORF, Verified
Description	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome (1, 2, 3)
Name Description	SURF Homolog of Yeast 1

Chromosomal Location	ChrVII:717358 to 718527 | ORF Map | GBrowse

	View Computational GO annotations for SHY1
Molecular Function
Manually curated	unfolded protein binding (IMP)
Biological Process
Manually curated	aerobic respiration (IMP) mitochondrial respiratory chain complex IV assembly (IMP, IPI)
Cellular Component
Manually curated	integral to membrane (IDA) mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	metal resistance: decreased respiratory growth: decreased rate
reduction of function	copper accumulation: decreased respiratory growth: absent
Large-scale survey
null	cell cycle progression in G1 phase: increased duration glycogen accumulation: decreased dessication resistance: decreased resistance to propan-1-ol: decreased resistance to ethanol: decreased resistance to sirolimus: increased resistance to tunicamycin: decreased resistance to wortmannin: normal resistance to edelfosine: decreased resistance to elesclomol-Cu: decreased respiratory growth: absent respiratory growth: decreased rate sporulation efficiency: decreased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	cell cycle progression: abnormal cell cycle progression in G1 phase: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-Western: 17 Co-fractionation: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 10 Negative Genetic: 14 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 1 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:717358 to 718527 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1170 717358..718527 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003344