SHU1/YHL006C Summary Help

Standard Name SHU1 1
Systematic Name YHL006C
Feature Type ORF, Verified
Description Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments (1, 2, 3, 4, 5, 6, 7)
Name Description Suppressor of HU sensitivity 1
Chromosomal Location
ChrVIII:98795 to 98343 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SHU1 GO evidence and references
  View Computational GO annotations for SHU1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
Large-scale survey
49 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Co-purification: 1
  • PCA: 1
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 8
  • Phenotypic Suppression: 4
  • Positive Genetic: 5
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 9

Expression Summary
Length (a.a.) 150
Molecular Weight (Da) 17,121
Isoelectric Point (pI) 8.43
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:98795 to 98343 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 2004-01-29
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..453 98795..98343 2011-02-03 2004-01-29
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000998
References cited on this page View Complete Literature Guide for SHU1
1) Shor E, et al.  (2005) A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics 169(3):1275-89
2) Huang ME, et al.  (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34
3) Mankouri HW, et al.  (2007) Shu proteins promote the formation of homologous recombination intermediates that are processed by sgs1-rmi1-top3. Mol Biol Cell 18(10):4062-73
4) Ball LG, et al.  (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102
5) Bernstein KA, et al.  (2011) The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Mol Biol Cell 22(9):1599-607
6) Sasanuma H, et al.  (2013) A new protein complex promoting the assembly of Rad51 filaments. Nat Commun 4():1676
7) Hong S and Kim KP  (2013) Shu1 promotes homolog bias of meiotic recombination in Saccharomyces cerevisiae. Mol Cells 36(5):446-54