Standard Name	SHR3 1
Systematic Name	YDL212W
Alias	APF1 2
Feature Type	ORF, Verified
Description	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface (1, 3, 4)
Name Description	Super high Histidine Resistant 1

Chromosomal Location	ChrIV:78426 to 79058 | ORF Map | GBrowse

	View Computational GO annotations for SHR3
Molecular Function
Manually curated	unfolded protein binding (IMP, IPI)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IGI, IPI) protein folding (IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA, ISS)
High-throughput	integral to membrane (ISM) mating projection tip (IDA)

Classical genetics
reduction of function	Dip5p-GFP accumulation: abnormal
unspecified	resistance to L-canavanine: increased resistance to DL-ethionine: increased resistance to beta-2-thienylalanine: increased resistance to L-thiosine: increased resistance to L-cycloserine: increased resistance to L-azetidine-2-carboxylic acid: increased resistance to DL-parafluorophenylalanine: increased resistance to cycloleucine: increased resistance to DL-norleucine: increased utilization of nitrogen source: absent utilization of nitrogen source: decreased
Large-scale survey
null	haploinsufficient inviable starvation resistance: decreased vegetative growth: normal
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	308 total interaction(s) for 246 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 3 Affinity Capture-Western: 5 Biochemical Activity: 1 Co-localization: 1 PCA: 64 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 7 Negative Genetic: 147 Phenotypic Enhancement: 4 Phenotypic Suppression: 4 Positive Genetic: 46 Synthetic Growth Defect: 5 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:78426 to 79058 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..633 78426..79058 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002371