SGV1/YPR161C Summary Help

SGV1 BASIC INFORMATION

Standard Name SGV1 1
Systematic Name YPR161C
Alias BUR1 2
Feature Type ORF, Verified
Description Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p (2, 3, 4, 5, 6, 7)
Name Description Suppressor of Gpa1Val50 mutation 1
GO Annotations All SGV1 GO evidence and references
    View Computational GO annotations for SGV1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SGV1 Phenotype details and references
Classical genetics
conditional
null
overexpression
reduction of function
unspecified
Large-scale survey
null
overexpression
reduction of function
Interactions SGV1 All interactions details and references
  View additional details at BioGRID
144 total interaction(s) for 114 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 80
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 6
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 16
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 8
  • Synthetic Rescue: 8
Sequence Information
ChrXVI:866418 to 864445 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1974 866418..864445 2004-07-21 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006365

SGV1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SGV1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SGV1]

1) Irie K, et al.  (1991) SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae. Cell 65(5):785-95
2) Prelich G and Winston F  (1993) Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo. Genetics 135(3):665-76
3) Yao S, et al.  (2000) BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo. Mol Cell Biol 20(19):7080-7
4) Murray S, et al.  (2001) Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase. Mol Cell Biol 21(13):4089-96
5) Yao S and Prelich G  (2002) Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1. Mol Cell Biol 22(19):6750-8
6) Keogh MC, et al.  (2003) Bur1 kinase is required for efficient transcription elongation by RNA polymerase II. Mol Cell Biol 23(19):7005-18
7) Liu Y, et al.  (2009) Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol 29(17):4852-63