SGT2/YOR007C Summary Help

Standard Name SGT2 1
Systematic Name YOR007C
Feature Type ORF, Verified
Description Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress (2, 3, 4, 5, 6, 7)
Name Description Small Glutamine-rich Tetratricopeptide repeat-containing protein 2
Chromosomal Location
ChrXV:339978 to 338938 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SGT2 GO evidence and references
  View Computational GO annotations for SGT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 14 genes
Classical genetics
Large-scale survey
164 total interaction(s) for 99 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 19
  • Co-crystal Structure: 3
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 66
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 9
  • Positive Genetic: 8
  • Synthetic Growth Defect: 5

Expression Summary
Length (a.a.) 346
Molecular Weight (Da) 37,218
Isoelectric Point (pI) 4.51
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:339978 to 338938 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1041 339978..338938 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005533
References cited on this page View Complete Literature Guide for SGT2
1) Liou ST, et al.  (2007) SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae. Cell Stress Chaperones 12(1):59-70
2) Kordes E, et al.  (1998) Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. Genomics 52(1):90-4
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Angeletti PC, et al.  (2002) Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity. Cell Stress Chaperones 7(3):258-68
5) Wang F, et al.  (2010) A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum. Mol Cell 40(1):159-71
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Kiktev DA, et al.  (2012) Regulation of chaperone effects on a yeast prion by cochaperone Sgt2. Mol Cell Biol 32(24):4960-70