SFT2/YBL102W Summary Help

Standard Name SFT2 1
Systematic Name YBL102W
Feature Type ORF, Verified
Description Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 (1, 2, 3 and see Summary Paragraph)
Name Description Suppressor of sed Five Ts 1
Chromosomal Location
ChrII:24098 to 24745 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SFT2 GO evidence and references
  View Computational GO annotations for SFT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Large-scale survey
null
overexpression
Resources
197 total interaction(s) for 106 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Co-localization: 1
  • PCA: 18
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 146
  • Positive Genetic: 17
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 215
Molecular Weight (Da) 24,274
Isoelectric Point (pI) 8.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:24098 to 24745 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-01-26 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..648 24098..24745 2004-01-26 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000198
SUMMARY PARAGRAPH for SFT2

Sft2p is a non-essential protein which colocalizes with Sft1p in the late Golgi cisternae, and interacts genetically with the early-Golgi "target" SNARE, Sed5p (1, 2). Sft2p has four predicted transmembrane domains, and can be used as a late Golgi marker to label Golgi membranes. Its N-terminus is predicted to be cytoplasmic (3). Sft2p appears to be involved in Golgi-to-endosome transport, but its precise function is currently undefined (2, 3).

Deletion of SFT2 is not normally lethal, but mutants have been isolated that require Sft2p for growth (3).

Last updated: 2005-06-07 Contact SGD

References cited on this page View Complete Literature Guide for SFT2
1) Banfield DK, et al.  (1995) A SNARE-like protein required for traffic through the Golgi complex. Nature 375(6534):806-9
2) Conchon S, et al.  (1999) Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex. EMBO J 18(14):3934-46
3) Wooding S and Pelham HR  (1998) The dynamics of golgi protein traffic visualized in living yeast cells. Mol Biol Cell 9(9):2667-80