Standard Name	SFI1 1
Systematic Name	YLL003W
Feature Type	ORF, Verified
Description	Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C (1, 2)
Name Description	Suppressor of Fermentation Induced loss of stress resistance 1

Chromosomal Location	ChrXII:143201 to 146041 | ORF Map | GBrowse

	View Computational GO annotations for SFI1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	G2/M transition of mitotic cell cycle (IMP) spindle assembly (IMP) spindle pole body duplication associated with nuclear envelope (IMP)
Cellular Component
Manually curated	half bridge of spindle pole body (IDA)

Classical genetics
conditional	cell cycle progression: arrested heat sensitivity: increased
null	inviable
overexpression	heat sensitivity: increased
repressible	cell cycle progression in G2 phase: arrested
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	57 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-Western: 4 Biochemical Activity: 1 Protein-peptide: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 16 Synthetic Growth Defect: 3 Synthetic Lethality: 13
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:143201 to 146041 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2841 143201..146041 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003926