SET5/YHR207C Summary Help

Standard Name SET5 1
Systematic Name YHR207C
Feature Type ORF, Verified
Description Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus (2, 3, 4, 5)
Name Description SET domain-containing 6
Chromosomal Location
ChrVIII:516485 to 514905 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SET5 GO evidence and references
  View Computational GO annotations for SET5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Large-scale survey
50 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 8
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 19
  • Phenotypic Suppression: 1
  • Positive Genetic: 10
  • Synthetic Growth Defect: 4
  • Synthetic Haploinsufficiency: 1

Expression Summary
Length (a.a.) 526
Molecular Weight (Da) 60,547
Isoelectric Point (pI) 6.43
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:516485 to 514905 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1581 516485..514905 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001250
References cited on this page View Complete Literature Guide for SET5
1) Haarer B, et al.  (2007) Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies. Genes Dev 21(2):148-59
2) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
3) Kushner DB, et al.  (2003) Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Proc Natl Acad Sci U S A 100(26):15764-9
4) Wlodarski T, et al.  (2011) Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome. PLoS One 6(8):e23168
5) Green EM, et al.  (2012) Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.LID - 10.1038/nsmb.2252 [doi] Nat Struct Mol Biol ()
6) Nislow C, et al.  (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36