SET3/YKR029C Summary Help

SET3 BASIC INFORMATION

Standard Name SET3
Systematic Name YKR029C
Feature Type ORF, Verified
Description Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains (1, 2, 3 and see Summary Paragraph)
Name Description SET domain-containing 4
GO Annotations All SET3 GO evidence and references
    View Computational GO annotations for SET3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SET3 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions SET3 All interactions details and references
174 total interaction(s) for 103 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 2
  • Affinity Capture-MS: 32
  • Affinity Capture-Western: 11
Genetic Interactions
  • Phenotypic Enhancement: 84
  • Phenotypic Suppression: 25
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 14
  • Synthetic Rescue: 2
Sequence Information
ChrXI:499475 to 497220 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2256 499475..497220 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001737

SET3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SET3

SUMMARY PARAGRAPH for SET3

Set3 is one of two proteins in yeast that, like Drosophila Trithorax, contains both SET and PHD domains (5). Set3p forms a complex called Set3C with Snt1p, Sif2p, cyclophilin Cpr1p, Hos2p, Hos4p, and Hst1p, that includes both NAD-dependent and NAD-independent histone deacetylase activities (6, 2). Set3C represses early/middle sporulation genes, including those encoding key meiotic regulators such as the IME2 protein kinase and the NDT80 transcription factor (1). Hst1p is also present in a complex with transcriptional repressor Sum1p. However, Hst1p is not required for meiotic repression by Set3C, suggesting that Set3C (without Hst1p) and not Hst1p-Sum1p, is the meiotic-specific repressor of early/middle sporulation genes (1).

Homology searches suggest that Set3C is the yeast analog of the mammalian HDAC3/SMRT complex (1).

Last updated: 2005-04-26

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SET3]

1) Pijnappel WW, et al.  (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004
2) Wang A, et al.  (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4
3) Krogan NJ, et al.  (2003) Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol 23(12):4207-18
4) Nislow C, et al.  (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36
5) Aasland R, et al.  (1995) The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 20(2):56-9
6) Arevalo-Rodriguez M and Heitman J  (2005) Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Eukaryot Cell 4(1):17-29