SET2/YJL168C Summary Help

SET2 BASIC INFORMATION

Standard Name SET2 1
Systematic Name YJL168C
Alias EZL1
Feature Type ORF, Verified
Description Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p (2, 3, 4, 5)
Name Description SET domain-containing 6
Gene Product Alias KMT3 7
GO Annotations All SET2 GO evidence and references
    View Computational GO annotations for SET2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SET2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SET2 All interactions details and references
346 total interaction(s) for 217 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Co-localization: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Growth Defect: 2
  • Phenotypic Enhancement: 103
  • Phenotypic Suppression: 30
  • Synthetic Growth Defect: 44
  • Synthetic Lethality: 123
  • Synthetic Rescue: 7
Sequence Information
ChrX:104422 to 102221 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2006-01-18 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2202 104422..102221 2006-01-18 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003704

SET2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SET2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SET2]

1) Hesman, T. and M. Johnston  (1997) SET2p contains both SET and CXC domains and regulates GAL4 expression. Unpublished
2) Strahl BD, et al.  (2002) Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol 22(5):1298-306
3) Xiao T, et al.  (2003) Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev 17(5):654-63
4) Schaft D, et al.  (2003) The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation. Nucleic Acids Res 31(10):2475-82
5) Li B, et al.  (2003) The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II. J Biol Chem 278(11):8897-903
6) Nislow C, et al.  (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6