SET1/YHR119W Summary Help

Standard Name SET1 1
Systematic Name YHR119W
Alias YTX1
Feature Type ORF, Verified
Description Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain (2, 3, 4, 5, 6, 7)
Name Description SET domain-containing 1
Gene Product Alias KMT2 8
Chromosomal Location
ChrVIII:346043 to 349285 | ORF Map | GBrowse
Gene Ontology Annotations All SET1 GO evidence and references
  View Computational GO annotations for SET1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Classical genetics
Large-scale survey
265 total interaction(s) for 134 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 79
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 15
  • Biochemical Activity: 6
  • Co-crystal Structure: 6
  • Co-fractionation: 1
  • Co-localization: 3
  • Co-purification: 16
  • Protein-RNA: 4
  • Reconstituted Complex: 10
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 27
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 11
  • Positive Genetic: 3
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 8
  • Synthetic Rescue: 38

Expression Summary
Length (a.a.) 1,080
Molecular Weight (Da) 123,911
Isoelectric Point (pI) 9.68
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:346043 to 349285 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3243 346043..349285 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001161
References cited on this page View Complete Literature Guide for SET1
1) Nislow C, et al.  (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
4) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
5) Boa S, et al.  (2003) Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression. Yeast 20(9):827-35
6) Cheng H, et al.  (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43
7) Terzi N, et al.  (2011) H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol 31(17):3569-83
8) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6