SEG1/YMR086W Summary Help

Standard Name SEG1 1, 2
Systematic Name YMR086W
Feature Type ORF, Verified
Description Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication (3, 4, 5, 6, 7, 8, 9)
Name Description Stability of Eisosomes Guaranteed 1
Chromosomal Location
ChrXIII:439208 to 442090 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SEG1 GO evidence and references
  View Computational GO annotations for SEG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
47 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 31
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 2
  • Co-localization: 1
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 7
  • Phenotypic Enhancement: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 960
Molecular Weight (Da) 105,873
Isoelectric Point (pI) 10.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:439208 to 442090 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2883 439208..442090 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004692
References cited on this page View Complete Literature Guide for SEG1
1) Seger S and Philippsen P  (2010) personal communication
2) Douglas LM, et al.  (2011) Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane. Membranes (Basel) 1(4):394-411
3) Tadi D, et al.  (1999) Selection of genes repressed by cAMP that are induced by nutritional limitation in Saccharomyces cerevisiae. Yeast 15(16):1733-45
4) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
5) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Deng C, et al.  (2009) Unifying fluorescence microscopy and mass spectrometry for studying protein complexes in cells. Mol Cell Proteomics 8(6):1413-23
8) Seger S, et al.  (2011) Formation and stability of eisosomes in the filamentous fungus Ashbya gossypii. J Cell Sci 124(Pt 10):1629-34
9) Moreira KE, et al.  (2012) Seg1 controls eisosome assembly and shape. J Cell Biol 198(3):405-20