Standard Name	SEC6 1
Systematic Name	YIL068C
Feature Type	ORF, Verified
Description	Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p (2, 3, 4, 5, 6)
Name Description	SECretory

Chromosomal Location	ChrIX:235474 to 233057 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SEC6
Molecular Function
Manually curated	protein homodimerization activity (IDA) SNARE binding (IDA, IPI)
Biological Process
Manually curated	exocyst localization (IMP) exocytosis (IMP) Golgi to plasma membrane transport (IGI, IMP) negative regulation of SNARE complex assembly (IDA, IGI, IPI) vesicle tethering involved in exocytosis (IC)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) exocyst (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
conditional	endomembrane system morphology: abnormal invertase secretion: decreased invertase accumulation: increased FusMidp distribution: abnormal
Large-scale survey
null	inviable
reduction of function	competitive fitness: normal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	141 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 1 Affinity Capture-Western: 27 Co-fractionation: 5 Co-purification: 4 PCA: 6 Reconstituted Complex: 5 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 6 Negative Genetic: 1 Phenotypic Enhancement: 7 Phenotypic Suppression: 13 Synthetic Growth Defect: 4 Synthetic Lethality: 30 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:235474 to 233057 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2418 235474..233057 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001330