Standard Name	SEC39
Systematic Name	YLR440C
Alias	DSL3 1
Feature Type	ORF, Verified
Description	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope (2, 3, 4)
Name Description	SECretory

Chromosomal Location	ChrXII:1017697 to 1015568 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SEC39
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER-dependent peroxisome organization (IMP) retrograde vesicle-mediated transport, Golgi to ER (IGI, IPI) vesicle-mediated transport (IMP)
Cellular Component
Manually curated	Dsl1p complex (IDA) endoplasmic reticulum (IDA) endoplasmic reticulum membrane (IDA) nuclear envelope (IDA) colocalizes_with peroxisome (IDA)
High-throughput	endoplasmic reticulum (IDA) nuclear envelope (IDA)

Classical genetics
repressible	endoplasmic reticulum morphology: abnormal nuclear morphology: abnormal peroxisomal morphology: abnormal peroxisomal protein distribution: abnormal Pmp2GFP-KKTN distribution: decreased Carboxypeptidase Y (CPY) distribution: abnormal
Large-scale survey
conditional	colony sectoring: increased heat sensitivity: increased
null	inviable
reduction of function	chromosome/plasmid maintenance: abnormal competitive fitness: decreased
repressible	cell shape: abnormal protein transport: abnormal Pmp2GFP-LRKR distribution: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	79 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Biochemical Activity: 1 Co-fractionation: 1 Co-localization: 1 Co-purification: 4 Reconstituted Complex: 2 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 14 Positive Genetic: 1 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:1017697 to 1015568 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2130 1017697..1015568 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004432