SEC39/YLR440C Summary Help

Standard Name SEC39
Systematic Name YLR440C
Alias DSL3 1
Feature Type ORF, Verified
Description Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope (2, 3, 4)
Name Description SECretory
Chromosomal Location
ChrXII:1017697 to 1015568 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SEC39 GO evidence and references
  View Computational GO annotations for SEC39
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
repressible
Large-scale survey
conditional
null
reduction of function
repressible
Resources
81 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 28
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 10
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 4
  • Reconstituted Complex: 2
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Negative Genetic: 14
  • Positive Genetic: 2
  • Synthetic Lethality: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 709
Molecular Weight (Da) 82,395
Isoelectric Point (pI) 4.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:1017697 to 1015568 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2130 1017697..1015568 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004432
References cited on this page View Complete Literature Guide for SEC39
1) Kraynack BA, et al.  (2005) Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell 16(9):3963-77
2) Mnaimneh S, et al.  (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118(1):31-44
3) Ishikawa T, et al.  (2005) Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. J Gen Appl Microbiol 51(1):73-82
4) Tripathi A, et al.  (2009) Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol 16(2):114-23