SEC28/YIL076W Summary

SEC28 BASIC INFORMATION

Standard Name	SEC28
Systematic Name	YIL076W
Alias	ANU2
Feature Type	ORF, Verified
Description	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth (1)
Name Description	SECretory

GO Annotations	All SEC28 GO evidence and references
	View Computational GO annotations for SEC28
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) late endosome to vacuole transport via multivesicular body sorting pathway (IMP, IPI) vesicle coating (IGI, IMP)
Cellular Component
Manually curated	COPI vesicle coat (IMP, ISS) colocalizes_with endosome (IDA)

Mutant Phenotype	All SEC28 Phenotype details and references
Classical genetics
null	heat sensitivity: increased carboxypeptidase Y secretion: abnormal resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: normal resistance to mercaptoethanol: normal resistance to FK506: decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased viable
Large-scale survey
null	competitive fitness: decreased lifespan: increased replicative lifespan: increased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to ethanol: decreased resistance to propan-1-ol: decreased resistance to pyocyanin: decreased resistance to tunicamycin: decreased viable

Interactions	SEC28 All interactions details and references
	View additional details at BioGRID
	561 total interaction(s) for 318 unique genes/features.
Physical Interactions	Affinity Capture-MS: 42 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 410 Phenotypic Suppression: 2 Positive Genetic: 84 Synthetic Growth Defect: 3 Synthetic Lethality: 12 Synthetic Rescue: 1

Sequence Information

ChrIX:216655 to 217545 | |

Last Update

Coordinates: 2005-11-22 | Sequence: 2005-11-22

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..891	216655..217545	2005-11-22	2005-11-22

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001338

SEC28 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SEC28

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC28]

1)	Duden R, et al. (1998) epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. EMBO J 17(4):985-95

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