SEC28/YIL076W Summary Help

Standard Name SEC28
Systematic Name YIL076W
Alias ANU2
Feature Type ORF, Verified
Description Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress (1, 2)
Name Description SECretory
Chromosomal Location
ChrIX:216658 to 217548 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SEC28 GO evidence and references
  View Computational GO annotations for SEC28
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
619 total interaction(s) for 340 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 70
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Co-crystal Structure: 2
  • Protein-peptide: 3
  • Reconstituted Complex: 3
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 419
  • Phenotypic Suppression: 2
  • Positive Genetic: 86
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 12
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 296
Molecular Weight (Da) 33,829
Isoelectric Point (pI) 4.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:216658 to 217548 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-11-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..891 216658..217548 2011-02-03 2005-11-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001338
References cited on this page View Complete Literature Guide for SEC28
1) Duden R, et al.  (1998) epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. EMBO J 17(4):985-95
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76