Standard Name	SEC27 1
Systematic Name	YGL137W
Feature Type	ORF, Verified
Description	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP (1, 2, 3)
Name Description	SECretory

Chromosomal Location	ChrVII:249869 to 252738 | ORF Map | GBrowse

	View Computational GO annotations for SEC27
Molecular Function
Manually curated	ubiquitin binding (IDA)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) late endosome to vacuole transport via multivesicular body sorting pathway (IMP, IPI) retrograde vesicle-mediated transport, Golgi to ER (IMP)
Cellular Component
Manually curated	COPI vesicle coat (IGI, ISS)

Classical genetics
conditional	carboxypeptidase Y secretion: abnormal carboxypeptidase Y secretion: decreased
null	inviable spore germination: absent
repressible	Pmp2GFP-KKTN distribution: decreased
Large-scale survey
null	inviable resistance to clioquinol: decreased toxin resistance: decreased
reduction of function	competitive fitness: normal
repressible	cell cycle progression in S phase: abnormal mitochondrial morphology: abnormal Pmp2GFP-LRKR distribution: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	379 total interaction(s) for 235 unique genes/features.
Physical Interactions	Affinity Capture-MS: 138 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 PCA: 30 Protein-peptide: 1 Protein-RNA: 1 Reconstituted Complex: 5 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 6 Negative Genetic: 167 Positive Genetic: 9 Synthetic Growth Defect: 1 Synthetic Lethality: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:249869 to 252738 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..18 249869..249886 2011-02-03 1996-07-31 Intron 19..218 249887..250086 2011-02-03 1996-07-31 CDS 219..2870 250087..252738 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (19 - 218)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003105