SEC22/YLR268W Summary Help

SEC22 BASIC INFORMATION

Standard Name SEC22 1
Systematic Name YLR268W
Alias SLY2 , TSL26
Feature Type ORF, Verified
Description R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog (2, 3)
Name Description SECretory 4
GO Annotations All SEC22 GO evidence and references
    View Computational GO annotations for SEC22
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SEC22 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions SEC22 All interactions details and references
489 total interaction(s) for 289 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 34
  • Co-fractionation: 4
  • Co-purification: 3
  • FRET: 3
  • Reconstituted Complex: 22
  • Two-hybrid: 13
Genetic Interactions
  • Dosage Rescue: 21
  • Phenotypic Enhancement: 268
  • Phenotypic Suppression: 53
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 45
  • Synthetic Rescue: 4
Sequence Information
ChrXII:680202 to 680846 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..645 680202..680846 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004258

SEC22 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SEC22

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC22]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Liu Y and Barlowe C  (2002) Analysis of Sec22p in endoplasmic reticulum/Golgi transport reveals cellular redundancy in SNARE protein function. Mol Biol Cell 13(9):3314-24
3) Liu Y, et al.  (2004) Sec22p export from the endoplasmic reticulum is independent of SNARE pairing. J Biol Chem 279(26):27225-32
4) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62