Standard Name	SEC22 1
Systematic Name	YLR268W
Alias	SLY2 , TSL26
Feature Type	ORF, Verified
Description	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog (2, 3)
Name Description	SECretory 4

Chromosomal Location	ChrXII:680200 to 680844 | ORF Map | GBrowse

	View Computational GO annotations for SEC22
Molecular Function
Manually curated	SNAP receptor activity (IDA)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) retrograde vesicle-mediated transport, Golgi to ER (IMP) vesicle fusion (IDA) vesicle fusion with endoplasmic reticulum (IC) vesicle fusion with Golgi apparatus (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) ER to Golgi transport vesicle membrane (IDA) Golgi apparatus (IDA) integral to membrane (IDA) SNARE complex (IDA)

Classical genetics
conditional	endomembrane system morphology: abnormal endoplasmic reticulum morphology: abnormal invertase secretion: decreased invertase accumulation: increased GFP-Sfh5p distribution: abnormal
null	glycogen accumulation: increased metal resistance: decreased Gas1p modification: decreased resistance to ferrozine(2-): decreased
Large-scale survey
conditional	resistance to benomyl: decreased
null	alkaline pH resistance: decreased anaerobic growth: decreased auxotrophy budding pattern: abnormal cell size: increased glycogen accumulation: increased rubidium(1+) accumulation: decreased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased lipid particle morphology: abnormal metal resistance: decreased mitochondrial genome maintenance: abnormal protein transport: abnormal resistance to sirolimus: decreased resistance to hydroxyurea: decreased resistance to spermine: decreased resistance to hygromycin B: decreased resistance to methyl methanesulfonate: decreased resistance to quinine: decreased resistance to arsenite(3-): decreased resistance to mycophenolic acid: decreased resistance to Calcofluor White: decreased resistance to fluconazole: increased resistance to caffeine: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to pyocyanin: decreased resistance to tunicamycin: decreased resistance to dimethyl sulfoxide: decreased resistance to edelfosine: decreased resistance to mefloquine: decreased resistance to ciclopirox olamine: decreased resistance to clioquinol: decreased resistance to acrolein: decreased respiratory growth: decreased rate sporulation: decreased sporulation: absent sporulation efficiency: decreased toxin resistance: decreased transposable element transposition: increased utilization of iron source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	845 total interaction(s) for 447 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 3 Affinity Capture-Western: 43 Co-fractionation: 5 Co-purification: 3 FRET: 3 PCA: 5 Reconstituted Complex: 25 Two-hybrid: 16
Genetic Interactions	Dosage Rescue: 25 Negative Genetic: 452 Phenotypic Enhancement: 48 Phenotypic Suppression: 70 Positive Genetic: 71 Synthetic Growth Defect: 31 Synthetic Lethality: 29 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:680200 to 680844 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..645 680200..680844 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004258