Standard Name	SEC21 1
Systematic Name	YNL287W
Feature Type	ORF, Verified
Description	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo (2, 3)
Name Description	SECretory

Chromosomal Location	ChrXIV:91994 to 94801 | ORF Map | GBrowse

	View Computational GO annotations for SEC21
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) retrograde vesicle-mediated transport, Golgi to ER (IMP)
Cellular Component
Manually curated	COPI vesicle coat (IDA) colocalizes_with endosome (IDA)

Classical genetics
conditional	endoplasmic reticulum morphology: abnormal carboxypeptidase Y secretion: decreased invertase accumulation: increased
repressible	Pmp2GFP-KKTN distribution: decreased
Large-scale survey
null	inviable resistance to clioquinol: decreased
overexpression	resistance to sirolimus: decreased vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased
repressible	mitochondrial morphology: abnormal Pmp2GFP-LRKR distribution: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	141 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-RNA: 2 Affinity Capture-Western: 14 Biochemical Activity: 1 Co-crystal Structure: 2 Co-fractionation: 4 PCA: 6 Protein-peptide: 1 Reconstituted Complex: 6 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 9 Negative Genetic: 14 Phenotypic Enhancement: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 17 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:91994 to 94801 | ORF Map | GBrowse
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2808 91994..94801 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005231