SEC14/YMR079W Summary 
| Standard Name | SEC14 1 |
|---|---|
| Systematic Name | YMR079W |
| Alias | PIT1 2 , 3 |
| Feature Type | ORF, Verified |
| Description | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication (4, 5, 6, 7, 8) |
| Name Description | SECretory 9 |
| Chromosomal Location | |
|---|---|
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Gene Ontology Annotations All SEC14 GO evidence and references
| View Computational GO annotations for SEC14 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated |
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| Cellular Component | |
| Manually curated |
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Mutant phenotypes All SEC14 Phenotype evidence and references
| Classical genetics | |
|---|---|
| conditional |
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| null | |
| Large-scale survey | |
| conditional | |
| null | |
| overexpression | |
| reduction of function | |
| repressible | |
| Resources |
interactions All SEC14 Interaction evidence and references
| 286 total interaction(s) for 185 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All SEC14 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004684 |
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References cited on this page View Complete Literature Guide for SEC14
| 1) | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
| 2) | Aitken JF, et al. (1990) The gene encoding the phosphatidylinositol transfer protein is essential for cell growth. J Biol Chem 265(8):4711-7 |
| 3) | Bankaitis VA, et al. (1990) An essential role for a phospholipid transfer protein in yeast Golgi function. Nature 347(6293):561-2 |
| 4) | Yanagisawa LL, et al. (2002) Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Mol Biol Cell 13(7):2193-206 |
| 5) | Schnabl M, et al. (2003) Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Eur J Biochem 270(15):3133-45 |
| 6) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 7) | Mousley CJ, et al. (2008) Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell 19(11):4785-803 |
| 8) | Curwin AJ, et al. (2013) Localization of lipid raft proteins to the plasma membrane is a major function of the phospholipid transfer protein sec14. PLoS One 8(1):e55388 |
| 9) | Novick P and Schekman R (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62 |
