Standard Name	SEC10 1
Systematic Name	YLR166C
Feature Type	ORF, Verified
Description	Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion (2, 3, 4)
Name Description	SECretory 5

Chromosomal Location	ChrXII:498044 to 495429 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SEC10
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	exocytosis (IMP) Golgi to plasma membrane transport (IGI, IMP) vesicle tethering involved in exocytosis (IC)
Cellular Component
Manually curated	exocyst (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
conditional	cytokinesis: decreased endomembrane system morphology: abnormal invertase secretion: decreased invertase accumulation: increased Chs2p-GFP distribution: abnormal
Large-scale survey
null	haploproficient inviable resistance to clioquinol: decreased
reduction of function	competitive fitness: increased
repressible	chromosome/plasmid maintenance: decreased mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	207 total interaction(s) for 105 unique genes/features.
Physical Interactions	Affinity Capture-MS: 85 Affinity Capture-Western: 19 Co-fractionation: 1 Co-purification: 1 PCA: 1 Reconstituted Complex: 8 Two-hybrid: 12
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 8 Dosage Rescue: 10 Negative Genetic: 18 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 6 Synthetic Lethality: 32 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:498044 to 495429 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2616 498044..495429 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004156