SEC1/YDR164C Summary Help

Standard Name SEC1 1, 2
Systematic Name YDR164C
Feature Type ORF, Verified
Description Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p (3, 4, 5)
Name Description SECretory 1
Chromosomal Location
ChrIV:784215 to 782041 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 94.77 cM
Gene Ontology Annotations All SEC1 GO evidence and references
  View Computational GO annotations for SEC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
reduction of function
Large-scale survey
null
overexpression
reduction of function
Resources
190 total interaction(s) for 86 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 25
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 4
  • Reconstituted Complex: 23
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 5
  • Dosage Rescue: 26
  • Negative Genetic: 20
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Positive Genetic: 5
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 39
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 724
Molecular Weight (Da) 83,480
Isoelectric Point (pI) 7.3
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:784215 to 782041 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 94.77 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2175 784215..782041 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002571
References cited on this page View Complete Literature Guide for SEC1
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Carr CM, et al.  (1999) Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol 146(2):333-44
4) Scott BL, et al.  (2004) Sec1p directly stimulates SNARE-mediated membrane fusion in vitro. J Cell Biol 167(1):75-85
5) Morgera F, et al.  (2012) Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1. Mol Biol Cell 23(2):337-46