SUMMARY PARAGRAPH for SDO1
SDO1 encodes a <42273>60S ribosome maturation factor associated with pre-60S ribosomes and polysomes where it functions in the release and recycling of pre-60S constituent Tif6p. Tif6p is required for efficient processing of rRNA and for pre-60S ribosome nuclear export. Tif6p shuttles between the nucleus and cytoplasm and its release from pre-60S ribosomes is a key-step in 60S maturation and subsequent translational activation of ribosomes (1 and references therein).42273>
Sdo1p is highly conserved among archae and eukaryotes (4). Mutations in the human ortholog, SBDS, cause Shwachman-Diamond syndrome (aka Shwachman-Bodian-Diamond syndrome), an autosomal recessive disease characterized by pancreatic insufficiency, skeletal abnormalities, bone marrow failure and a predisposition to leukemia. Another S. cerevisiae protein, YHR087W, contains the same unusual structural domain found in SBDS and orthologs, but does not display similarity beyond this domain (2 and 3).
The sdo1 deletion mutant has been variously reported both as inviable (7) and as having a slow-growth phenotype (1).
Last updated: 2007-03-26