SDH4/YDR178W Summary Help

Standard Name SDH4 1
Systematic Name YDR178W
Alias ACN18
Feature Type ORF, Verified
Description Membrane anchor subunit of succinate dehydrogenase; involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; SDH4 has a paralog, SHH4, that arose from the whole genome duplication (2, 3)
Name Description Succinate DeHydrogenase 1
Chromosomal Location
ChrIV:817950 to 818495 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SDH4 GO evidence and references
  View Computational GO annotations for SDH4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Resources
48 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Co-localization: 1
  • PCA: 2
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 29
  • Phenotypic Suppression: 1
  • Positive Genetic: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 181
Molecular Weight (Da) 20,248
Isoelectric Point (pI) 9.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:817950 to 818495 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..546 817950..818495 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002585
References cited on this page View Complete Literature Guide for SDH4
1) Chapman KB, et al.  (1992) SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Gene 118(1):131-6
2) Oyedotun KS and Lemire BD  (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279(10):9424-31
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61