SDH2/YLL041C Summary

SDH2 BASIC INFORMATION

Standard Name	SDH2 1
Systematic Name	YLL041C
Alias	ACN17
Feature Type	ORF, Verified
Description	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone (2) Also known as: SDHB 3
Name Description	Succinate DeHydrogenase 1

GO Annotations	All SDH2 GO evidence and references
	View Computational GO annotations for SDH2
Molecular Function
Manually curated	succinate dehydrogenase (ubiquinone) activity (IDA, IGI, IMP)
Biological Process
Manually curated	cellular respiration (IGI, IMP) mitochondrial electron transport, succinate to ubiquinone (TAS) tricarboxylic acid cycle (IMP)
Cellular Component
Manually curated	mitochondrial membrane (IDA) mitochondrial respiratory chain complex II (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Mutant Phenotype	All SDH2 Phenotype details and references
Classical genetics
null	Sdh5p accumulation: increased respiratory growth: decreased rate
unspecified	utilization of carbon source: absent
Large-scale survey
null	respiratory growth: decreased rate respiratory growth: absent viable

Interactions	SDH2 All interactions details and references
	8 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Reconstituted Complex: 1
Genetic Interactions	Synthetic Growth Defect: 2

Sequence Information

ChrXII:53930 to 53130 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..801	53930..53130	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003964

SDH2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SDH2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SDH2]

1)	Chapman KB, et al. (1992) SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Gene 118(1):131-6
2)	Oyedotun KS and Lemire BD (2004) The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J Biol Chem 279(10):9424-31
3)	Robinson KM, et al. (1991) Isolation and characterization of a Saccharomyces cerevisiae mutant disrupted for the succinate dehydrogenase flavoprotein subunit. J Biol Chem 266(32):21347-50

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