SCS3/YGL126W Summary Help

Standard Name SCS3 1
Systematic Name YGL126W
Alias FIT2B 2
Feature Type ORF, Verified
Description Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol (1, 2, 3)
Name Description Suppressor of Choline Sensitivity 1
Chromosomal Location
ChrVII:270997 to 272139 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SCS3 GO evidence and references
  View Computational GO annotations for SCS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
135 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 113
  • Positive Genetic: 9
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 380
Molecular Weight (Da) 42,735
Isoelectric Point (pI) 10.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:270997 to 272139 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1143 270997..272139 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003094
References cited on this page View Complete Literature Guide for SCS3
1) Hosaka K, et al.  (1994) Cloning and sequence of the SCS3 gene which is required for inositol prototrophy in Saccharomyces cerevisiae. J Biochem (Tokyo) 116(6):1317-21
2) Kadereit B, et al.  (2008) Evolutionarily conserved gene family important for fat storage. Proc Natl Acad Sci U S A 105(1):94-9
3) Moir RD, et al.  (2012) SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR. PLoS Genet 8(8):e1002890