SCO2/YBR024W Summary Help

Standard Name SCO2 1
Systematic Name YBR024W
Feature Type ORF, Verified
Description Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication (2, 3)
Name Description Suppressor of Cytochrome Oxidase deficiency 1
Chromosomal Location
ChrII:289445 to 290350 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SCO2 GO evidence and references
  View Computational GO annotations for SCO2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
42 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 30
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 301
Molecular Weight (Da) 34,888
Isoelectric Point (pI) 8.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:289445 to 290350 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..906 289445..290350 2004-07-16 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000228
References cited on this page View Complete Literature Guide for SCO2
1) Glerum DM, et al.  (1996) SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J Biol Chem 271(34):20531-5
2) Lode A, et al.  (2002) Molecular characterization of Saccharomyces cerevisiae Sco2p reveals a high degree of redundancy with Sco1p. Yeast 19(11):909-22
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61