Standard Name	SCC2 1
Systematic Name	YDR180W
Feature Type	ORF, Verified
Description	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin (1, 2, 3, 4, 5)
Name Description	Sister Chromatid Cohesion 1

Chromosomal Location	ChrIV:821295 to 825776 | ORF Map | GBrowse

	View Computational GO annotations for SCC2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	2-micrometer plasmid partitioning (IC) double-strand break repair (IMP) establishment of mitotic sister chromatid cohesion (IMP) establishment of protein localization to chromatin (IMP) mitotic chromosome condensation (IMP) protein localization to chromatin (IMP) rDNA condensation (IMP) transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery (IMP) tRNA gene clustering (IMP)
Cellular Component
Manually curated	2-micrometer circle DNA (IDA) nuclear chromatin (IDA) SMC loading complex (IPI)

Classical genetics
conditional	Brn1p distribution: abnormal
unspecified	heat sensitivity: increased nucleolar morphology: abnormal
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal colony sectoring: increased
null	haploinsufficient inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	158 total interaction(s) for 117 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-localization: 1 Two-hybrid: 14
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 108 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 4 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:821295 to 825776 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4482 821295..825776 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002588