Standard Name	SBA1 1
Systematic Name	YKL117W
Feature Type	ORF, Verified
Description	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description	increased Sensitivity to Benzoquinone Ansamycins 1

Chromosomal Location	ChrXI:220324 to 220974 | ORF Map | GBrowse

Molecular Function
Manually curated	chaperone binding (IMP, IPI)
Biological Process
Manually curated	positive regulation of telomere maintenance via telomerase (IDA, IMP) protein folding (IMP, IPI) regulation of telomerase activity (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	colony sectoring: increased telomere length: decreased viable
Large-scale survey
null	competitive fitness: increased filamentous growth: decreased haploinsufficient invasive growth: absent Fus-Mid-GFP distribution: abnormal resistance to methyl methanesulfonate: decreased starvation resistance: decreased viable
overexpression	colony sectoring: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	424 total interaction(s) for 326 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 3 Affinity Capture-Western: 10 Biochemical Activity: 1 Co-crystal Structure: 1 PCA: 1 Reconstituted Complex: 83 Two-hybrid: 86
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 10 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 210
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:220324 to 220974 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..651 220324..220974 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001600