SAS3/YBL052C Summary Help

SAS3 BASIC INFORMATION

Standard Name SAS3 1
Systematic Name YBL052C
Feature Type ORF, Verified
Description Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality (1, 2, 3)
Name Description Something About Silencing 1
Gene Product Alias KAT6 4
GO Annotations All SAS3 GO evidence and references
    View Computational GO annotations for SAS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SAS3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SAS3 All interactions details and references
  View additional details at BioGRID
91 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Co-localization: 1
  • Co-purification: 2
  • Two-hybrid: 2
Genetic Interactions
  • Negative Genetic: 22
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 7
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 6
Sequence Information
ChrII:121877 to 119382 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2496 121877..119382 2004-07-16 1997-01-28
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000148

SAS3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SAS3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAS3]

1) Reifsnyder C, et al.  (1996) Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14(1):42-9
2) John S, et al.  (2000) The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev 14(10):1196-208
3) Howe L, et al.  (2001) Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev 15(23):3144-54
4) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6